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Old Elizabethan Sir Demis Hassabis has been awarded the Nobel prize for chemistry, jointly with a colleague at the AI company he founded and with an American scientist.

Demis (OE 1988–1990), who is the co-founder and CEO of AI company Google DeepMind, receives half of the prize with his DeepMind colleague, Dr John Jumper, for their work on predicting complex protein structures. The other half of the prize awarded by the Royal Swedish Academy of Sciences goes to Professor David Baker, from the University of Washington, for his work on protein design.

In their statement, the prize committee wrote: “Demis Hassabis and John Jumper have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. These discoveries hold enormous potential.

“Since the 1970s, researchers had tried to predict protein structures from amino acid sequences, but this was notoriously difficult. However, four years ago, there was a stunning breakthrough.

“In 2020, Demis Hassabis and John Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified.”

The Nobel Committee emphasised the global impact of AlphaFold2. It has been accessed by more than two million researchers from 190 countries. Examples of its many applications include: helping scientists to understand better antibiotic resistance; and creating images of enzymes that can decompose plastic.

Reacting to the news, Demis, 48, said: “It’s totally surreal to be honest, quite overwhelming.”

He explained the “funny sequence” through which he actually heard the news that he was a Nobel laureate. Since the committee did not apparently have a telephone number for him, they had reached him through a Teams call to his wife, who was working on her laptop at the time. After at first ignoring it, she answered it at around the third or fourth call. The caller then requested to be put in touch with Demis, whom they asked for Dr Jumper’s number.

Demis thanked his colleagues, including Dr Jumper, adding: “David Baker we’ve got to know in the last few years, and he’s done some absolutely seminal work in protein design. So it’s really, really exciting to receive the prize with both of them.”

The Nobel prize committee praised the work of Professor Baker, which he began in 2003, saying that he had “succeeded with the almost impossible feat of building entirely new kinds of proteins.”

The committee’s statement concluded: “Life could not exist without proteins. That we can now predict protein structures and design our own proteins confers the greatest benefit to humankind.”

The illustration above shows a selection of protein structures determined using AlfaFold2 (©Terezia Kovalova/The Royal Swedish Academy of Sciences).

• The scientific background to the 2024 Nobel prize for chemistry can be read here. A popular-level introduction is available here.

The 2024 School Play delved deep into the tumultuous events that marked the decades-long run-up to Indian independence in 1947.

Lions and Tigers explored not only the conflict between the eponymous British lions and Bengal tigers, but also between factions of the independence movement, including those, led by Gandhi, who espoused civil disobedience, and those favouring violent insurrection.

Written by British playwright Tanika Gupta, the play combines the story of her great-uncle, Dinesh Gupta, a 19-year-old Indian freedom-fighter hanged by the British in 1931 after shooting dead the Inspector-General of Prisons, with the broader history of the fight for Indian independence.

Congratulating all involved, Headmaster Neil Enright said: “The production did not shy away from the pain, violence and brutality of the period, but dealt with the complex issues sensitively and conveyed the emotional depth of the characters. It was impactful and, at times, shocking, yet done with a gravitas and maturity that belied the age of some of the young performers.”

Lions and Tigers was first performed in 2017 at the Sam Wanamaker Playhouse in Southwark, coinciding with the 70^th anniversary of Indian independence.

QE’s production involved 15 boys in the principal roles, supported by an acting ensemble playing other parts.

Two very well attended performances were held after school on consecutive days in the Main School Hall, while Year 9 attended a final dress rehearsal.

“The play was notable for a host of powerful and impassioned performances,” said Mr Enright. “The whole cast, including the ensemble, did a brilliant job, with Akshay Shah setting the tone with an amazing performance as the central character, Dinesh Gupta.”

Other notable mentions should go to Daniel Kollo as Charles Tegart, Nittant Moudgil as Mahatma Gandhi, Soham Sapra as Subhash Bose, and Aahan Shah as Jyotish Gupta, he added.

“It was nice to see a good number of other pupils attending, whether aspiring actors, older students who have been part of the QE drama community, or those who were just there to support friends.”

The play was directed by RM Drama’s Gavin Molloy. Musical support was provided by QE’s Indian Music Ensemble.

Assistant Head (Pupil Involvement) Crispin Bonham-Carter lauded the “immersive and visually interesting staging”, which was done ‘in the round’, as well as “the clever and effective use of newsreel footage and recorded voice-overs”. One example of the latter was that the actors had voiced in advance the words to the letters their characters had sent (as set out in the script): these were then played through the sound system while the boys acted out what had been written.

• Click on the thumbnails below to view the images.

Both QE teams have qualified for the final, global round of the World Economics Cup – with ‘Team 2’ coming first and  ‘Team 1’ second in Europe.

Their success in the continental round and, before that, at the national round, comes in the first year that QE boys have entered the competition.

The boys, now in Year 13, found the opportunity themselves and entered on their own initiative, with the School then supporting them by negotiating down the cost of entry, given QE’s status as a state school.

Headmaster Neil Enright said: “The results, announced recently, reveal the quite remarkable success of our young economists: this is a huge achievement. I offer my congratulations to both teams. They should be especially commended on their dedication: with their continental round taking place during the summer holidays, the boys had to collaborate digitally, and that involved lots of Zoom calls, one reportedly going on until 2am!”

“We wish them all the best for the final round, which takes place in a few days’ time.”

The boys’ successful ‘cup run’ began last term when the two teams both won gold awards in the UK round. In fact all 12 boys achieved ‘highest distinction’ individual awards, while four team members, Avi Juneja, Saim Khan, Rohan Varia and Uday Dash, were also national ‘top 10 scorers’.

In each round of the competition, entrants have to tackle three modules, entitled Fundamentals, Deep Comprehension and Thinking & Innovation. Teams from 47 countries competed in this year’s World Economics Cup. There were five continental rounds, including the European one.

Modules 1 and 2 each have around 100 questions that every person on the team has to answer. The team score was the aggregated average – which meant there could be no ‘weak links’ among the six-strong teams.

The deep comprehension round also introduces case studies, alongside data and university-style lectures, to test how participants understand, interpret and analyse new information.

Team 2’s Saim Khan said: “The deep-thinking segment gave me a new appreciation for the depth of consideration that must be given from all angles when it comes to economic policy-making and implementing.”

Module 3 is fully collaborative and involves delivering a 15-minute video presentation, identifying problems and solutions based upon a brief. The brief is the same for all teams, but only released the day before the submission deadline – so competitors have no more than 24 hours to respond. In the continental round, the module revolved around a healthcare company that planned to introduce AI and robots into the workforce.

For Andreas Angelopoulos, of Team 2, this was a highlight: “I particularly enjoyed collaborating with my teammates on our solution to the Thinking & Innovation portion of the European round, in which we proposed a framework that ‘MediTech Innovations’ could use to implement AI into the workforce ecosystem.”

For his part, Team 1 member Ishtarth Katageri relished the sheer challenge of this module: “Collaborating with my team mates when we had a day to respond was difficult, especially with some team members in different countries at the time.”

Team 2’s Uday Dash reflected on the event so far: “Being able to refine my problem-solving skills in the context of an international economics competition is a unique thrill that I am incredibly appreciative of!”

And Uday’s teammate, Zaki Mustafa, expressed a similar view: “The competition has been a great opportunity to apply our economics knowledge practically, in areas such as ‘fintech’ and cryptocurrency mining. I’m really proud to have reached the finals with a great team.”

Tejas Bansal added: “Participating in the World Economics Cup has been an amazing experience for us – coming first in the European round was a huge achievement, and I found the presentation part especially rewarding. We look forward to the final round!”

Team 1
Kush Mandan
Avi Juneja
Shrey Tater
Hari Kumarappan
Shreyaas Sandeep
Ishtarth Katageri

Team 2
Saim Khan
Rohan Varia
Uday Dash
Zaki Mustafa
Andreas Angelopoulos
Tejas Bansal

• Most of the QE competitors are pictured above, with members of both teams at the top, then Team 2, then Team 1.

Ninety-five Year 10 boys headed off to Aberdovey for a long weekend of outdoor activities and team-building on the Welsh coast.

After the successful inaugural trip last year, the 2024 cohort again enjoyed activities that required them to learn new skills and, in many cases, to pluck up a little courage. This year, alongside the canoeing, climbing, hiking and shimmying along a rope above water, they could also practise abseiling and making a fire.

A further change from 2023’s dual trips was that the whole group went together, making the long coach journey on the same weekend.

QE Flourish tutor Celia Wallace, who led the boys and a team of eight staff, said: “It was a great weekend: the boys returned tired but exhilarated, with fresh skills learned, a few fears faced and overcome, new friendships forged, and with existing friendships deepened.”

“Through the Flourish programme, we are committed to offering our students a wide range of extra-curricular opportunities,” Dr Wallace added. “Trips such as this develop the boys not only as individuals, but in their capacity for helping one another and working as a team.”

After a journey broken by a 30-minute stop at services, the boys eventually arrived at the Outward Bound centre in Aberdovey (Aberdyfi) in Snowdonia National Park, where they were to sleep in dormitories.

Several of the participants spoke about their experience after it was all over. Krish Deebak and Parth Jain both welcomed being taken out of their ‘comfort zone’ through activities such as rock-climbing and gorge-scrambling. Tanush Madadi said: “The fact that we managed to do such a range of activities in such a short span of time was really an amazing thing.”

It was, said several, fun to try out new activities, with Namish Thakur commenting that “it was also a great way to learn new things about myself, like the fact that I’m somehow pretty good at dragging myself across a rope”.

Many of the boys readily appreciated that the benefits extended well beyond the acquisition of new physical skills. Henry Greene learned “important life lessons”, such as skills in “communication and leadership”; Alex Wang found that the trip “helped build up my confidence and leadership,”; Sriram Muthukumaran said: “It was a great opportunity to get to know others in our year that we may not be so familiar with.”

They also enjoyed the chance to do it all in a picturesque location. Danyal Rahim said: “I think my highlight of the trip would be any time we went to the beach, as it was such a beautiful landscape.”

Aryan Afghan reflected widely on the weekend. He liked the “really nice” food; the clean dormitories with “ample room” and the “great attitude” of the instructors. He thanked Dr Wallace and her team, even endorsing their decision to remove boys’ phones for the weekend. “A great idea – many of us felt a lot happier and more awake without them, and some of us didn’t want to use them on the way back because we learnt from Aberdovey that we, in fact, don’t need to be stuck to a screen all the time to have fun and enjoy ourselves.”

This was, as Suhaan Panjwani said, a time for “making many memories”, or, as Aaryav Sharma commented, summing it all up: “It was incredible.”

• To view the images below, click on the thumbnails.

Year 13 Geography and English Literature students joined forces on a trip to see John Steinbeck’s Depression-era novel, The Grapes of Wrath, at the National Theatre.

The 1939 novel tells the story of a tenant-farmer family from Oklahoma who struggle to survive during the Dust Bowl, a period of severe dust storms that greatly damaged agriculture in the American prairies during the 1930s.

The book is a set text for the English A-level students, while for the geographers, the story illustrates the inter-relational nature of phenomena such as drought & desertification, mass migration and food security.

Head of English Robert Hyland said: “The Grapes of Wrath is, among other things, an environmental and ecological novel. Teaming up with the Geography department to run this trip was a great way of highlighting how seemingly disparate subjects like English and Geography can shed light on the climate crisis which affects us all.”

He added that it is helpful for English Literature students to see a performance of a novel at the start of their study of it, since it helps them understand the characters and narrative.

Deputy Head (Academic) and Geography teacher Anne Macdonald said: “The novel addresses significant geographical themes linked to people’s relationship with the environment, mass migration caused by climate change and environmental degradation, and the shattered dream of a better life experienced by migrants searching for a new home. While set in 1930s America, its themes are relevant to the current world on the brink of mass migration caused by climate change.”

The Grapes of Wrath recounts the Joad family’s journey west to California in a dilapidated lorry as they pursue a better life. It ends with the story’s protagonist, Tom Joad, going into hiding after killing a policeman who murdered his friend for organising a strike, and with the family’s eldest daughter, Rose of Sharon, breastfeeding a starving man to save his life.

On its publication, it caused considerable controversy because of its negative depiction of the USA of the time.

Epic in its scope, the story was retold in a three-hour performance at the National Theatre, produced by Carrie Cracknell, which followed Frank Galati’s 1998 play, based closely on the novel.

Some of the pupils gave their reactions afterwards:

• Geography student Andreas Angelopolous said: “I found the portrayal of the Dust Bowl migration powerful. The depiction of the Joads’ struggle against poverty and discrimination was compelling and mirrors challenges faced by many migrants today.”
• His fellow geographer, Saim Khan, said: “It brought to life just how deeply influential the topics we learn in the classroom – like drought – are in shaping the lives of people around the world. There are few forms of media more able to capture sense of place than theatre.”
• English Literature student Vaibhav Gaddi said that the story “demonstrated the resilience of the human spirit when encountered with intense hardship. The Joad family endures death, miscarriage and losing family members, and yet are still unbowed at the play’s shocking end.”

Mrs Macdonald and Assistant Head of English Victoria Maule accompanied the boys on the trip to the South Bank.